The role of phospholipase D in regulated exocytosis

Tatiana P. Rogasevskaia; Jens R. Coorssen

doi:10.1074/jbc.M115.681429

The role of phospholipase D in regulated exocytosis

Tatiana P. Rogasevskaia, Jens R. Coorssen

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Phospholipase D (PLD)-derived phosphatidic acid (PA) is suggested to function in exocytosis. Results: PLD activity on the plasma membrane was higher than on vesicles. PLD inhibitors suppressed some fusion parameters, but blockade of PA did not affect fusion. Conclusion: PLD-derived PA has modulatory rather than direct effects on fusion. Significance: Identifying critical mechanistic components may enable interventions to target diseases affecting exocytosis.

Original language	English
Pages (from-to)	28683-28696
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	290
Issue number	48
DOIs	https://doi.org/10.1074/jbc.M115.681429
Publication status	Published - 2015

Keywords

cell membranes
exocytosis
phosphatidic acids

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10.1074/jbc.M115.681429

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title = "The role of phospholipase D in regulated exocytosis",

abstract = "Background: Phospholipase D (PLD)-derived phosphatidic acid (PA) is suggested to function in exocytosis. Results: PLD activity on the plasma membrane was higher than on vesicles. PLD inhibitors suppressed some fusion parameters, but blockade of PA did not affect fusion. Conclusion: PLD-derived PA has modulatory rather than direct effects on fusion. Significance: Identifying critical mechanistic components may enable interventions to target diseases affecting exocytosis.",

keywords = "cell membranes, exocytosis, phosphatidic acids",

author = "Rogasevskaia, {Tatiana P.} and Coorssen, {Jens R.}",

year = "2015",

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AU - Rogasevskaia, Tatiana P.

AU - Coorssen, Jens R.

PY - 2015

Y1 - 2015

N2 - Background: Phospholipase D (PLD)-derived phosphatidic acid (PA) is suggested to function in exocytosis. Results: PLD activity on the plasma membrane was higher than on vesicles. PLD inhibitors suppressed some fusion parameters, but blockade of PA did not affect fusion. Conclusion: PLD-derived PA has modulatory rather than direct effects on fusion. Significance: Identifying critical mechanistic components may enable interventions to target diseases affecting exocytosis.

AB - Background: Phospholipase D (PLD)-derived phosphatidic acid (PA) is suggested to function in exocytosis. Results: PLD activity on the plasma membrane was higher than on vesicles. PLD inhibitors suppressed some fusion parameters, but blockade of PA did not affect fusion. Conclusion: PLD-derived PA has modulatory rather than direct effects on fusion. Significance: Identifying critical mechanistic components may enable interventions to target diseases affecting exocytosis.

KW - cell membranes

KW - exocytosis

KW - phosphatidic acids

UR - http://handle.uws.edu.au:8081/1959.7/uws:33117

U2 - 10.1074/jbc.M115.681429

DO - 10.1074/jbc.M115.681429

M3 - Article

SN - 0021-9258

VL - 290

SP - 28683

EP - 28696

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 48

ER -

The role of phospholipase D in regulated exocytosis

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