The roles of cathepsins Bl and D in the digestion of cytoplasmic proteins in vitro by lysosomal extracts

R. T. Dean

doi:10.1016/0006-291X(76)91176-1

The roles of cathepsins Bl and D in the digestion of cytoplasmic proteins in vitro by lysosomal extracts

R. T. Dean

University College London

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

By means of the inhibitors leupeptin and pepstatin it is shown that both thiol proteinases (such as cathepsin Bl) and the acid proteinase cathepsin D play substantial roles in the degradation in vitro of cytoplasmic proteins by mixtures of lysosomal enzymes.

Original language	English
Pages (from-to)	518-523
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(76)91176-1
Publication status	Published - 26 Jan 1976
Externally published	Yes

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title = "The roles of cathepsins Bl and D in the digestion of cytoplasmic proteins in vitro by lysosomal extracts",

abstract = "By means of the inhibitors leupeptin and pepstatin it is shown that both thiol proteinases (such as cathepsin Bl) and the acid proteinase cathepsin D play substantial roles in the degradation in vitro of cytoplasmic proteins by mixtures of lysosomal enzymes.",

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AB - By means of the inhibitors leupeptin and pepstatin it is shown that both thiol proteinases (such as cathepsin Bl) and the acid proteinase cathepsin D play substantial roles in the degradation in vitro of cytoplasmic proteins by mixtures of lysosomal enzymes.

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JO - Biochemical and Biophysical Research Communications

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The roles of cathepsins Bl and D in the digestion of cytoplasmic proteins in vitro by lysosomal extracts

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