Abstract
Dinuclear (2,2':6',2''-terpyridine)platinum(II) (PtTerpy) complexes were synthesised by tethering either thiol or pyridine based linkers. All intermediates and resulting complexes were characterised using a combination of 1H and 195Pt NMR, two-dimensional 1H correlation spectroscopy (NOSY/COSY), two-dimensional 1H/195Pt heteronuclear multiple bond correlation spectroscopy (HMQC), elemental analysis and electrospray ionisation mass spectrometry (ESI-MS). The cytotoxicity of the complexes was determined against human A2780 ovarian carcinoma cells and its cisplatinresistant sub-line A2780cis, as well as L1210 murine leukemia cells.
| Original language | English |
|---|---|
| Pages (from-to) | 87-96 |
| Number of pages | 10 |
| Journal | Dalton Transactions |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- cytotoxicity
- platinum compounds
- terpyridine
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