The synthesis, characterisation and cytotoxicity of bisintercalating (2,2':6',2''-terpyridine)platinum(II) complexes

Benjamin W. J. Harper; Janice R. Aldrich-Wright

doi:10.1039/C4DT02773F

The synthesis, characterisation and cytotoxicity of bisintercalating (2,2':6',2''-terpyridine)platinum(II) complexes

Benjamin W. J. Harper, Janice R. Aldrich-Wright

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29 Citations (Scopus)

Abstract

Dinuclear (2,2':6',2''-terpyridine)platinum(II) (PtTerpy) complexes were synthesised by tethering either thiol or pyridine based linkers. All intermediates and resulting complexes were characterised using a combination of 1H and 195Pt NMR, two-dimensional 1H correlation spectroscopy (NOSY/COSY), two-dimensional 1H/195Pt heteronuclear multiple bond correlation spectroscopy (HMQC), elemental analysis and electrospray ionisation mass spectrometry (ESI-MS). The cytotoxicity of the complexes was determined against human A2780 ovarian carcinoma cells and its cisplatinresistant sub-line A2780cis, as well as L1210 murine leukemia cells.

Original language	English
Pages (from-to)	87-96
Number of pages	10
Journal	Dalton Transactions
Volume	44
Issue number	1
DOIs	https://doi.org/10.1039/C4DT02773F https://doi.org/10.1039/c4dt02773f
Publication status	Published - 2015

Keywords

cytotoxicity
platinum compounds
terpyridine

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AU - Harper, Benjamin W. J.

AU - Aldrich-Wright, Janice R.

PY - 2015

Y1 - 2015

N2 - Dinuclear (2,2':6',2''-terpyridine)platinum(II) (PtTerpy) complexes were synthesised by tethering either thiol or pyridine based linkers. All intermediates and resulting complexes were characterised using a combination of 1H and 195Pt NMR, two-dimensional 1H correlation spectroscopy (NOSY/COSY), two-dimensional 1H/195Pt heteronuclear multiple bond correlation spectroscopy (HMQC), elemental analysis and electrospray ionisation mass spectrometry (ESI-MS). The cytotoxicity of the complexes was determined against human A2780 ovarian carcinoma cells and its cisplatinresistant sub-line A2780cis, as well as L1210 murine leukemia cells.

AB - Dinuclear (2,2':6',2''-terpyridine)platinum(II) (PtTerpy) complexes were synthesised by tethering either thiol or pyridine based linkers. All intermediates and resulting complexes were characterised using a combination of 1H and 195Pt NMR, two-dimensional 1H correlation spectroscopy (NOSY/COSY), two-dimensional 1H/195Pt heteronuclear multiple bond correlation spectroscopy (HMQC), elemental analysis and electrospray ionisation mass spectrometry (ESI-MS). The cytotoxicity of the complexes was determined against human A2780 ovarian carcinoma cells and its cisplatinresistant sub-line A2780cis, as well as L1210 murine leukemia cells.

KW - cytotoxicity

KW - platinum compounds

KW - terpyridine

UR - http://handle.uws.edu.au:8081/1959.7/uws:29595

U2 - 10.1039/C4DT02773F

DO - 10.1039/C4DT02773F

M3 - Article

C2 - 25407567

SN - 1477-9226

VL - 44

SP - 87

EP - 96

JO - Dalton Transactions

JF - Dalton Transactions

IS - 1

ER -

The synthesis, characterisation and cytotoxicity of bisintercalating (2,2':6',2''-terpyridine)platinum(II) complexes

Abstract

Keywords

UN SDGs

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