The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection

J. Nattermann; G. Ahlenstiel; T. Berg; G. Feldmann; H. D. Nischalke; T. Müller; J. Rockstroh; R. Woitas; T. Sauerbruch; U. Spengler

doi:10.1111/j.1365-2893.2005.00652.x

The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection

J. Nattermann
, G. Ahlenstiel
, T. Berg
, G. Feldmann
, H. D. Nischalke
, T. Müller
, J. Rockstroh
, R. Woitas
, T. Sauerbruch
, U. Spengler

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The C-type lectin DC-SIGNR has been shown to bind hepatitis C virus (HCV). Here, we analysed the tandem-repeat polymorphism of the DC-SIGNR gene with respect to intraindividual HCV replication. In a cross-sectional comparison HCV-infected patients (n = 430) and healthy subjects (n = 100) were genotyped for the DC-SIGNR polymorphism using PCR. The distribution of DC-SIGNR alleles did not differ significantly between the two groups. However, HCV-infected patients with 5-, 6-, and 7-repeat alleles had higher HCV-RNA levels when compared with carriers of 4- and 9-repeat alleles (P < 0.05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.

Original language	English
Pages (from-to)	42-46
Number of pages	5
Journal	Journal of Viral Hepatitis
Volume	13
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2893.2005.00652.x
Publication status	Published - Jan 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CD209L
DC-SIGNR
Genetic polymorphisms
HCV
L-SIGN

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10.1111/j.1365-2893.2005.00652.x

Cite this

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title = "The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection",

abstract = "The C-type lectin DC-SIGNR has been shown to bind hepatitis C virus (HCV). Here, we analysed the tandem-repeat polymorphism of the DC-SIGNR gene with respect to intraindividual HCV replication. In a cross-sectional comparison HCV-infected patients (n = 430) and healthy subjects (n = 100) were genotyped for the DC-SIGNR polymorphism using PCR. The distribution of DC-SIGNR alleles did not differ significantly between the two groups. However, HCV-infected patients with 5-, 6-, and 7-repeat alleles had higher HCV-RNA levels when compared with carriers of 4- and 9-repeat alleles (P < 0.05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.",

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AU - Nattermann, J.

AU - Ahlenstiel, G.

AU - Berg, T.

AU - Feldmann, G.

AU - Nischalke, H. D.

AU - Müller, T.

AU - Rockstroh, J.

AU - Woitas, R.

AU - Sauerbruch, T.

AU - Spengler, U.

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AB - The C-type lectin DC-SIGNR has been shown to bind hepatitis C virus (HCV). Here, we analysed the tandem-repeat polymorphism of the DC-SIGNR gene with respect to intraindividual HCV replication. In a cross-sectional comparison HCV-infected patients (n = 430) and healthy subjects (n = 100) were genotyped for the DC-SIGNR polymorphism using PCR. The distribution of DC-SIGNR alleles did not differ significantly between the two groups. However, HCV-infected patients with 5-, 6-, and 7-repeat alleles had higher HCV-RNA levels when compared with carriers of 4- and 9-repeat alleles (P < 0.05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.

KW - CD209L

KW - DC-SIGNR

KW - Genetic polymorphisms

KW - HCV

KW - L-SIGN

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The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection

Abstract

UN SDGs

Keywords

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