The TGF-β high producer genotype is associated with response to HCV-specific therapy in HIV-positive patients with acute hepatitis C

J. Nattermann; M. Vogel; H. D. Nischalke; M. Danta; G. Ahlenstiel; M. Michalk; T. Sauerbruch; J. Rockstroh; U. Spengler

The TGF-β high producer genotype is associated with response to HCV-specific therapy in HIV-positive patients with acute hepatitis C

J. Nattermann, M. Vogel, H. D. Nischalke, M. Danta, G. Ahlenstiel, M. Michalk, T. Sauerbruch, J. Rockstroh, U. Spengler

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Co-infection with the Hepatitis C virus (HCV) in HIVpositive patients is an emerging health problem. The factors affecting response to HCV-specific therapy are poorly understood but may involve host genetic factors. HCV NS5A-induced inhibition of TGF-b signaling has been suggested as a potential mechanism involved in HCV pathogenesis. TGF-b, a multifunctional cytokine, displays gene polymorphisms (TGF-b codon 10 T/C and codon 25G/C) associated with differential cytokine secretion. Here, we studied whether TGF-b gene polymorphisms affect the treatment response in HCV/HIV co-infection.

Original language	English
Pages (from-to)	S305-S306
Number of pages	1
Journal	Journal of Hepatology
Volume	48
Publication status	Published - 2008

Keywords

cytokines
genetic polymorphisms
hepatitis C virus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "The TGF-β high producer genotype is associated with response to HCV-specific therapy in HIV-positive patients with acute hepatitis C",

abstract = "Background: Co-infection with the Hepatitis C virus (HCV) in HIVpositive patients is an emerging health problem. The factors affecting response to HCV-specific therapy are poorly understood but may involve host genetic factors. HCV NS5A-induced inhibition of TGF-b signaling has been suggested as a potential mechanism involved in HCV pathogenesis. TGF-b, a multifunctional cytokine, displays gene polymorphisms (TGF-b codon 10 T/C and codon 25G/C) associated with differential cytokine secretion. Here, we studied whether TGF-b gene polymorphisms affect the treatment response in HCV/HIV co-infection.",

keywords = "cytokines, genetic polymorphisms, hepatitis C virus",

author = "J. Nattermann and M. Vogel and Nischalke, {H. D.} and M. Danta and G. Ahlenstiel and M. Michalk and T. Sauerbruch and J. Rockstroh and U. Spengler",

year = "2008",

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journal = "Journal of Hepatology",

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TY - JOUR

T1 - The TGF-β high producer genotype is associated with response to HCV-specific therapy in HIV-positive patients with acute hepatitis C

AU - Nattermann, J.

AU - Vogel, M.

AU - Nischalke, H. D.

AU - Danta, M.

AU - Ahlenstiel, G.

AU - Michalk, M.

AU - Sauerbruch, T.

AU - Rockstroh, J.

AU - Spengler, U.

PY - 2008

Y1 - 2008

N2 - Background: Co-infection with the Hepatitis C virus (HCV) in HIVpositive patients is an emerging health problem. The factors affecting response to HCV-specific therapy are poorly understood but may involve host genetic factors. HCV NS5A-induced inhibition of TGF-b signaling has been suggested as a potential mechanism involved in HCV pathogenesis. TGF-b, a multifunctional cytokine, displays gene polymorphisms (TGF-b codon 10 T/C and codon 25G/C) associated with differential cytokine secretion. Here, we studied whether TGF-b gene polymorphisms affect the treatment response in HCV/HIV co-infection.

AB - Background: Co-infection with the Hepatitis C virus (HCV) in HIVpositive patients is an emerging health problem. The factors affecting response to HCV-specific therapy are poorly understood but may involve host genetic factors. HCV NS5A-induced inhibition of TGF-b signaling has been suggested as a potential mechanism involved in HCV pathogenesis. TGF-b, a multifunctional cytokine, displays gene polymorphisms (TGF-b codon 10 T/C and codon 25G/C) associated with differential cytokine secretion. Here, we studied whether TGF-b gene polymorphisms affect the treatment response in HCV/HIV co-infection.

KW - cytokines

KW - genetic polymorphisms

KW - hepatitis C virus

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:41521

M3 - Article

SN - 0168-8278

VL - 48

SP - S305-S306

JO - Journal of Hepatology

JF - Journal of Hepatology

ER -

The TGF-β high producer genotype is associated with response to HCV-specific therapy in HIV-positive patients with acute hepatitis C

Abstract

Keywords

UN SDGs

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