The TGF-β, PI3K/Akt and PTEN pathways : established and proposed biochemical integration in prostate cancer

Stephen J. Assinder; Qihan Dong; Zaklina Kovacevic; Des R. Richardson

doi:10.1042/BJ20081610

The TGF-β, PI3K/Akt and PTEN pathways : established and proposed biochemical integration in prostate cancer

Stephen J. Assinder, Qihan Dong, Zaklina Kovacevic, Des R. Richardson

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

A key to the development of improved pharmacological treatment strategies for cancer is an understanding of the integration of biochemical pathways involved in both tumorigenesis and cancer suppression. Furthermore, genetic markers that may predict the outcome of targeted pharmacological intervention in an individual are central to patient-focused treatment regimens rather than the traditional 'one size fits all' approach. Prostate cancer is a highly heterogenous disease in which a patient-tailored care program is a holy grail. This review will describe the evidence that demonstrates the integration of three established pathways: the tumour-suppressive TGF-β (transforming growth factor-β) pathway, the tumorigenic PI3K/Akt (phosphoinositide 3-kinase/protein kinase B) pathway and the tumour-suppressive PTEN (phosphatase and tensin homologue deleted on chromosome 10) pathway. It will discuss gene polymorphisms and somatic mutations in relevant genes and highlight novel pharmaceutical agents that target key points in these integrated pathways.

Original language	English
Pages (from-to)	411-421
Number of pages	11
Journal	Biochemical Journal
Volume	417
Issue number	2
DOIs	https://doi.org/10.1042/BJ20081610
Publication status	Published - 2009

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title = "The TGF-β, PI3K/Akt and PTEN pathways : established and proposed biochemical integration in prostate cancer",

abstract = "A key to the development of improved pharmacological treatment strategies for cancer is an understanding of the integration of biochemical pathways involved in both tumorigenesis and cancer suppression. Furthermore, genetic markers that may predict the outcome of targeted pharmacological intervention in an individual are central to patient-focused treatment regimens rather than the traditional 'one size fits all' approach. Prostate cancer is a highly heterogenous disease in which a patient-tailored care program is a holy grail. This review will describe the evidence that demonstrates the integration of three established pathways: the tumour-suppressive TGF-β (transforming growth factor-β) pathway, the tumorigenic PI3K/Akt (phosphoinositide 3-kinase/protein kinase B) pathway and the tumour-suppressive PTEN (phosphatase and tensin homologue deleted on chromosome 10) pathway. It will discuss gene polymorphisms and somatic mutations in relevant genes and highlight novel pharmaceutical agents that target key points in these integrated pathways.",

author = "Assinder, {Stephen J.} and Qihan Dong and Zaklina Kovacevic and Richardson, {Des R.}",

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T1 - The TGF-β, PI3K/Akt and PTEN pathways : established and proposed biochemical integration in prostate cancer

AU - Assinder, Stephen J.

AU - Dong, Qihan

AU - Kovacevic, Zaklina

AU - Richardson, Des R.

PY - 2009

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AB - A key to the development of improved pharmacological treatment strategies for cancer is an understanding of the integration of biochemical pathways involved in both tumorigenesis and cancer suppression. Furthermore, genetic markers that may predict the outcome of targeted pharmacological intervention in an individual are central to patient-focused treatment regimens rather than the traditional 'one size fits all' approach. Prostate cancer is a highly heterogenous disease in which a patient-tailored care program is a holy grail. This review will describe the evidence that demonstrates the integration of three established pathways: the tumour-suppressive TGF-β (transforming growth factor-β) pathway, the tumorigenic PI3K/Akt (phosphoinositide 3-kinase/protein kinase B) pathway and the tumour-suppressive PTEN (phosphatase and tensin homologue deleted on chromosome 10) pathway. It will discuss gene polymorphisms and somatic mutations in relevant genes and highlight novel pharmaceutical agents that target key points in these integrated pathways.

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DO - 10.1042/BJ20081610

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JO - Biochemical Journal

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ER -

The TGF-β, PI3K/Akt and PTEN pathways : established and proposed biochemical integration in prostate cancer

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