The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

Melanie M. Ashton; Olivia M. Dean; Adam J. Walker; Chiara C. Bortolasci; Chee H. Ng; Malcolm Hopwood; Brian H. Harvey; Marisa Moller; John J. McGrath; Wolfgang Marx; Alyna Turner; Seetal Dodd; James G. Scott; Jon-Paul Khoo; Ken Walder; Jerome Sarris; Michael Berk

doi:10.3389/fpsyt.2019.00115

The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

Melanie M. Ashton, Olivia M. Dean, Adam J. Walker, Chiara C. Bortolasci, Chee H. Ng, Malcolm Hopwood, Brian H. Harvey, Marisa Moller, John J. McGrath, Wolfgang Marx, Alyna Turner, Seetal Dodd, James G. Scott, Jon-Paul Khoo, Ken Walder, Jerome Sarris, Michael Berk

Western Sydney University

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.

Original language	English
Article number	115
Number of pages	17
Journal	Frontiers in Psychiatry
Volume	10
DOIs	https://doi.org/10.3389/fpsyt.2019.00115
Publication status	Published - 2019

Open Access - Access Right Statement

© 2019 Ashton, Dean, Walker, Bortolasci, Ng, Hopwood, Harvey, Möller, McGrath, Marx, Turner, Dodd, Scott, Khoo, Walder, Sarris and Berk. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Keywords

inflammation
mangosteen
manic-depressive illness
oxidative stress
psychiatry
schizophrenia

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10.3389/fpsyt.2019.00115

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Ashton, M. M., Dean, O. M., Walker, A. J., Bortolasci, C. C., Ng, C. H., Hopwood, M., Harvey, B. H., Moller, M., McGrath, J. J., Marx, W., Turner, A., Dodd, S., Scott, J. G., Khoo, J.-P., Walder, K., Sarris, J., & Berk, M. (2019). The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia. Frontiers in Psychiatry, 10, Article 115. https://doi.org/10.3389/fpsyt.2019.00115

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title = "The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia",

abstract = "New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.",

keywords = "inflammation, mangosteen, manic-depressive illness, oxidative stress, psychiatry, schizophrenia",

author = "Ashton, {Melanie M.} and Dean, {Olivia M.} and Walker, {Adam J.} and Bortolasci, {Chiara C.} and Ng, {Chee H.} and Malcolm Hopwood and Harvey, {Brian H.} and Marisa Moller and McGrath, {John J.} and Wolfgang Marx and Alyna Turner and Seetal Dodd and Scott, {James G.} and Jon-Paul Khoo and Ken Walder and Jerome Sarris and Michael Berk",

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language = "English",

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Ashton, MM, Dean, OM, Walker, AJ, Bortolasci, CC, Ng, CH, Hopwood, M, Harvey, BH, Moller, M, McGrath, JJ, Marx, W, Turner, A, Dodd, S, Scott, JG, Khoo, J-P, Walder, K, Sarris, J & Berk, M 2019, 'The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia', Frontiers in Psychiatry, vol. 10, 115. https://doi.org/10.3389/fpsyt.2019.00115

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AU - Ashton, Melanie M.

AU - Dean, Olivia M.

AU - Walker, Adam J.

AU - Bortolasci, Chiara C.

AU - Ng, Chee H.

AU - Hopwood, Malcolm

AU - Harvey, Brian H.

AU - Moller, Marisa

AU - McGrath, John J.

AU - Marx, Wolfgang

AU - Turner, Alyna

AU - Dodd, Seetal

AU - Scott, James G.

AU - Khoo, Jon-Paul

AU - Walder, Ken

AU - Sarris, Jerome

AU - Berk, Michael

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AB - New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.

KW - inflammation

KW - mangosteen

KW - manic-depressive illness

KW - oxidative stress

KW - psychiatry

KW - schizophrenia

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:50284

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DO - 10.3389/fpsyt.2019.00115

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VL - 10

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

M1 - 115

ER -

The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

Abstract

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Keywords

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