The unique characteristics of ON and OFF retinal ganglion cells : a modeling study

Tianruo Guo, David Tsai, John W. Morley, Gregg J. Suaning, Nigel H. Lovell, Socrates Dokos

    Research output: Chapter in Book / Conference PaperConference Paperpeer-review

    7 Citations (Scopus)

    Abstract

    ![CDATA[Retinal ganglion cells (RGCs) demonstrate a large range of variation in their ionic channel properties and morphologies. These cell-specific properties are responsible for the unique way they process synaptic inputs. A cell-specific modeling approach allows us to examine the functional significance of regional membrane channel expression and cell morphology. ON and OFF RGC models based on accurate biophysics and realistic representation of morphologies were used to study the contribution of different ion channel properties and spatial structure of neurons to RGC electrical activity. Using this approach, morphologically-complex retinal neurons such as amacrine cells or RGCs can be modelled and their interactions and processing can be better understood.]]
    Original languageEnglish
    Title of host publicationProceedings of 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Chicago, Illinois, USA, 26-30 August 2014
    PublisherIEEE
    Pages6096-6099
    Number of pages4
    ISBN (Print)9781424479276
    DOIs
    Publication statusPublished - 2014
    EventIEEE Engineering in Medicine and Biology Society. Annual Conference -
    Duration: 30 Apr 2015 → …

    Publication series

    Name
    ISSN (Print)1557-170X

    Conference

    ConferenceIEEE Engineering in Medicine and Biology Society. Annual Conference
    Period30/04/15 → …

    Keywords

    • retinal ganglion cells

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