The use of urea-based creams in the prevention of diabetic ulceration

Jackie Locke, Stuart Baird, Gordon Hendry

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Dermatological conditions such as anhydrosis (lack of sweat production), xerosis (abnormal dryness and scaling of skin), callous and fissuring increase the risk of ulceration in diabetic autonomic neuropathy. Patient education and topical application of emollients are effective in the prevention of these conditions, and may reduce the associated risk of ulceration. However, patient compliance is often difficult to achieve and multiple daily applications of emollient are considered demanding and inconvenient. With this in view, the use of an emollient that is effective in preventing dermatological conditions with a once-daily topical application may improve patient compliance and reduce the risk of diabetic ulceration. This review will consider the risk factors of and the causal pathways towards diabetic foot ulceration, and will discuss the clinical effectiveness of urea-based emollients as a targeted preventative intervention.
    Original languageEnglish
    Pages (from-to)26-32
    Number of pages7
    JournalDermatological Nursing
    Volume11
    Issue number2
    Publication statusPublished - 2012

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