TY - JOUR
T1 - To stress or not to stress? : exercise pulmonary haemodynamic testing in systemic sclerosis
AU - Lau, Edmund M. T.
AU - Thakkar, Vivek
AU - Humbert, Marc
AU - Herve, Philippe
PY - 2016
Y1 - 2016
N2 - Pulmonary arterial hypertension (PAH) is a leading cause of morbidity and mortality in systemic sclerosis(SSc) [1], and patients have a ∼10% lifetime risk of developing this devastating complication [2]. Despite targeted PAH therapy, outcomes of SSc-associated PAH (SSc-PAH) remain unsatisfactory, with a median survival of only 3–4 years from time of diagnosis [3, 4]. In the hope of further improving outcomes in SSc-PAH, early disease detection has been a major focus of research in the past decade [5–9]. One important and highly debated topic is the utility of exercise pulmonary haemodynamic testing for the early diagnosis of pulmonary vascular disease [10–12].
AB - Pulmonary arterial hypertension (PAH) is a leading cause of morbidity and mortality in systemic sclerosis(SSc) [1], and patients have a ∼10% lifetime risk of developing this devastating complication [2]. Despite targeted PAH therapy, outcomes of SSc-associated PAH (SSc-PAH) remain unsatisfactory, with a median survival of only 3–4 years from time of diagnosis [3, 4]. In the hope of further improving outcomes in SSc-PAH, early disease detection has been a major focus of research in the past decade [5–9]. One important and highly debated topic is the utility of exercise pulmonary haemodynamic testing for the early diagnosis of pulmonary vascular disease [10–12].
KW - mortality
KW - pulmonary hypertension
KW - systemic scleroderma
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:38647
U2 - 10.1183/13993003.01809-2016
DO - 10.1183/13993003.01809-2016
M3 - Article
SN - 0903-1936
VL - 48
SP - 1549
EP - 1552
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 6
ER -
