TY - JOUR
T1 - Towards a framework for better understanding of quiescent cancer cells
AU - Nabil, Wan Najbah Nik
AU - Xi, Zhichao
AU - Song, Zejia
AU - Jin, Lei
AU - Zhang, Xu Dong
AU - Zhou, Hua
AU - Souza, Paul De
AU - Dong, Qihan
AU - Xu, Hongxi
PY - 2021
Y1 - 2021
N2 - Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis. QCCs are also therapeutically challenging due to their resistance to most conventional cancer treatments that selectively act on proliferating cells. Considering the significant impact of QCCs on cancer progression and treatment, better understanding of appropriate experimental models, and the evaluation of QCCs are key questions in the field that have direct influence on potential pharmacological interventions. Here, this review focuses on existing and emerging preclinical models and detection methods for QCCs and discusses their respective features and scope for application. By providing a framework for selecting appropriate experimental models and investigative methods, the identification of the key players that regulate the survival and activation of QCCs and the development of more effective QCC-targeting therapeutic agents may mitigate the consequences of QCCs.
AB - Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis. QCCs are also therapeutically challenging due to their resistance to most conventional cancer treatments that selectively act on proliferating cells. Considering the significant impact of QCCs on cancer progression and treatment, better understanding of appropriate experimental models, and the evaluation of QCCs are key questions in the field that have direct influence on potential pharmacological interventions. Here, this review focuses on existing and emerging preclinical models and detection methods for QCCs and discusses their respective features and scope for application. By providing a framework for selecting appropriate experimental models and investigative methods, the identification of the key players that regulate the survival and activation of QCCs and the development of more effective QCC-targeting therapeutic agents may mitigate the consequences of QCCs.
UR - https://hdl.handle.net/1959.7/uws:63164
U2 - 10.3390/cells10030562
DO - 10.3390/cells10030562
M3 - Article
SN - 2073-4409
VL - 10
JO - Cells
JF - Cells
IS - 3
M1 - 562
ER -