Towards controlling functionally-distinct retinal ganglion cells in degenerate retina

Madhuvanthi Muralidharan; Tianruo Guo; Mohit N. Shivdasani; David Tsai; Shelley Fried; Morven Cameron; John W. Morley; Socrates Dokos; Nigel H. Lovell

doi:10.1109/EMBC44109.2020.9176595

Towards controlling functionally-distinct retinal ganglion cells in degenerate retina

Madhuvanthi Muralidharan, Tianruo Guo, Mohit N. Shivdasani, David Tsai, Shelley Fried, Morven Cameron, John W. Morley, Socrates Dokos, Nigel H. Lovell

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

4 Citations (Scopus)

Abstract

Present retinal neuroprostheses have limited performance capabilities due to indiscriminate activation of different neural pathways. Based on our success in differentially activating ON and OFF cells using high frequency stimuli in a healthy retina, in this study we explored whether we could achieve similar differential activation between these two cell types but in degenerate retina. We found that after blocking the synaptic network, ON retinal ganglion cells (RGCs) could be differentially activated at higher frequencies (4 - 6 kHz) and amplitudes (200 - 240 μA), and OFF RGCs at relatively lower amplitudes (80 - 160 μA) across all tested frequencies. We further found that both cell types could be controlled by quickly modulating the frequency using short stimulation bursts. This work takes us one step closer to reducing the likelihood of indiscriminate activation of RGCs by accurately controlling the activation of functionally-distinct neural pathways.

Original language	English
Title of host publication	Proceedings of the 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC '20), 20 - 24 July 2020, Virtual
Publisher	IEEE
Pages	3598-3601
Number of pages	4
ISBN (Print)	9781728119908
DOIs	https://doi.org/10.1109/EMBC44109.2020.9176595
Publication status	Published - Jul 2020
Event	IEEE Engineering in Medicine and Biology Society. Annual International Conference - Duration: 11 Jul 2022 → …

Publication series

Name
ISSN (Print)	1558-4615

Conference

Conference	IEEE Engineering in Medicine and Biology Society. Annual International Conference
Period	11/07/22 → …

Bibliographical note

Publisher Copyright:
© 2020 IEEE.

Keywords

prosthesis
retina
retinal degeneration
retinal ganglion cells

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10.1109/EMBC44109.2020.9176595

Cite this

Muralidharan, M., Guo, T., Shivdasani, M. N., Tsai, D., Fried, S., Cameron, M., Morley, J. W., Dokos, S., & Lovell, N. H. (2020). Towards controlling functionally-distinct retinal ganglion cells in degenerate retina. In Proceedings of the 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC '20), 20 - 24 July 2020, Virtual (pp. 3598-3601). Article 9176595 IEEE. https://doi.org/10.1109/EMBC44109.2020.9176595

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title = "Towards controlling functionally-distinct retinal ganglion cells in degenerate retina",

abstract = "Present retinal neuroprostheses have limited performance capabilities due to indiscriminate activation of different neural pathways. Based on our success in differentially activating ON and OFF cells using high frequency stimuli in a healthy retina, in this study we explored whether we could achieve similar differential activation between these two cell types but in degenerate retina. We found that after blocking the synaptic network, ON retinal ganglion cells (RGCs) could be differentially activated at higher frequencies (4 - 6 kHz) and amplitudes (200 - 240 μA), and OFF RGCs at relatively lower amplitudes (80 - 160 μA) across all tested frequencies. We further found that both cell types could be controlled by quickly modulating the frequency using short stimulation bursts. This work takes us one step closer to reducing the likelihood of indiscriminate activation of RGCs by accurately controlling the activation of functionally-distinct neural pathways.",

keywords = "prosthesis, retina, retinal degeneration, retinal ganglion cells",

author = "Madhuvanthi Muralidharan and Tianruo Guo and Shivdasani, {Mohit N.} and David Tsai and Shelley Fried and Morven Cameron and Morley, {John W.} and Socrates Dokos and Lovell, {Nigel H.}",

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year = "2020",

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doi = "10.1109/EMBC44109.2020.9176595",

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Muralidharan, M, Guo, T, Shivdasani, MN, Tsai, D, Fried, S, Cameron, M, Morley, JW, Dokos, S & Lovell, NH 2020, Towards controlling functionally-distinct retinal ganglion cells in degenerate retina. in Proceedings of the 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC '20), 20 - 24 July 2020, Virtual., 9176595, IEEE, pp. 3598-3601, IEEE Engineering in Medicine and Biology Society. Annual International Conference, 11/07/22. https://doi.org/10.1109/EMBC44109.2020.9176595

Towards controlling functionally-distinct retinal ganglion cells in degenerate retina. / Muralidharan, Madhuvanthi; Guo, Tianruo; Shivdasani, Mohit N. et al.
Proceedings of the 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC '20), 20 - 24 July 2020, Virtual. IEEE, 2020. p. 3598-3601 9176595.

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

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AU - Muralidharan, Madhuvanthi

AU - Guo, Tianruo

AU - Shivdasani, Mohit N.

AU - Tsai, David

AU - Fried, Shelley

AU - Cameron, Morven

AU - Morley, John W.

AU - Dokos, Socrates

AU - Lovell, Nigel H.

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AB - Present retinal neuroprostheses have limited performance capabilities due to indiscriminate activation of different neural pathways. Based on our success in differentially activating ON and OFF cells using high frequency stimuli in a healthy retina, in this study we explored whether we could achieve similar differential activation between these two cell types but in degenerate retina. We found that after blocking the synaptic network, ON retinal ganglion cells (RGCs) could be differentially activated at higher frequencies (4 - 6 kHz) and amplitudes (200 - 240 μA), and OFF RGCs at relatively lower amplitudes (80 - 160 μA) across all tested frequencies. We further found that both cell types could be controlled by quickly modulating the frequency using short stimulation bursts. This work takes us one step closer to reducing the likelihood of indiscriminate activation of RGCs by accurately controlling the activation of functionally-distinct neural pathways.

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Muralidharan M, Guo T, Shivdasani MN, Tsai D, Fried S, Cameron M et al. Towards controlling functionally-distinct retinal ganglion cells in degenerate retina. In Proceedings of the 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC '20), 20 - 24 July 2020, Virtual. IEEE. 2020. p. 3598-3601. 9176595 doi: 10.1109/EMBC44109.2020.9176595

Towards controlling functionally-distinct retinal ganglion cells in degenerate retina

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