Traditional Chinese medicine Shuang Shen Ning Xin attenuates myocardial ischemia/reperfusion injury by preserving of mitochondrial function

Xueli Li, Jianxun Liu, Li Lin, Yujie Guo, Chengren Lin, Cuixiang Zhang, Bin Yang

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

To investigate the potential cardioprotective effects of Shuang Shen Ning Xin on myocardial ischemia/reperfusion injury. Wistar rats were treated with trimetazidine (10 mg/kg/day, ig), Shuang Shen Ning Xin (22.5, 45 mg/kg/day, ig), or saline for 5 consecutive days. Myocardial ischemia/reperfusion injury was induced by ligation of the left anterior descending coronary artery for 40 min and reperfusion for 120 min on the last day of administration. It is found that Shuang Shen Ning Xin pretreatment markedly decreased infarct size and serum LDH levels, and this observed protection was associated with reduced myocardial oxidative stress and cardiomyocyte apoptosis after myocardial ischemia/reperfusion injury. In addition, further studies on mitochondrial function showed that rats treated with Shuang Shen Ning Xin displayed decreased mitochondrial swelling and cytosolic cytochrome c levels, which were accompanied by a preservation of complex I activities and inhibition of mitochondrial permeability transition. In conclusion, the mitochondrial protective effect of Shuang Shen Ning Xin could be a new mechanism, by which Shuang Shen Ning Xin attenuates myocardial ischemia/reperfusion injury.
Original languageEnglish
Article number180965
Number of pages11
JournalEvidence-Based Complementary and Alternative Medicine
Volume2014
DOIs
Publication statusPublished - 2014

Open Access - Access Right Statement

Copyright © 2014 Xueli Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • coronary heart disease
  • rats

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