Abstract
To better understand mechanisms by which arterial cells promote oxidation of low density lipoprotein (LDL), we investigated a role for the trans-plasma membrane electron transport (TPMET) system (which uses intracellular reductants to reduce extracellular acceptors, e.g., metal ions) of macrophages in cell-mediated LDL oxidation. We had previously shown that catalytic levels of extracellular transition metal ions are essential for cell-mediated oxidation of LDL; we studied how manipulation of TPMET activity of macrophages affects their ability to oxidize LDL in vitro.
Original language | English |
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Number of pages | 3 |
Journal | FASEB Journal |
DOIs | |
Publication status | Published - 2001 |
Open Access - Access Right Statement
©FASEBKeywords
- cells
- lipoproteins
- low density lipoproteins
- macrophages
- oxidation