Trans-plasma membrane electron transport induces macrophage-mediated low density lipoprotein oxidation

Anna Baoutina, Roger T. Dean, Wendy K. Jessup

    Research output: Contribution to journalArticle

    Abstract

    To better understand mechanisms by which arterial cells promote oxidation of low density lipoprotein (LDL), we investigated a role for the trans-plasma membrane electron transport (TPMET) system (which uses intracellular reductants to reduce extracellular acceptors, e.g., metal ions) of macrophages in cell-mediated LDL oxidation. We had previously shown that catalytic levels of extracellular transition metal ions are essential for cell-mediated oxidation of LDL; we studied how manipulation of TPMET activity of macrophages affects their ability to oxidize LDL in vitro.
    Original languageEnglish
    Number of pages3
    JournalFASEB Journal
    DOIs
    Publication statusPublished - 2001

    Open Access - Access Right Statement

    ©FASEB

    Keywords

    • cells
    • lipoproteins
    • low density lipoproteins
    • macrophages
    • oxidation

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