Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus

L. M. Kemp; P. M. Brickell; N. B. La Thangue; D. S. Latchman

doi:10.1007/BF01114970

Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus

L. M. Kemp
, P. M. Brickell
, N. B. La Thangue
, D. S. Latchman

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Herpes simplex virus Type 2 causes a severe repression of host cell biosynthesis at a number of levels. We show that despite this, non-viral cDNA clones derived from cellular RNA species which accumulate to high levels after infection can be isolated using differential screening techniques. By using nuclear run-off assays, we have shown that this RNA accumulation is mediated by transcriptional induction of the corresponding cellular genes.

Original language	English
Pages (from-to)	945-951
Number of pages	7
Journal	Bioscience Reports
Volume	6
Issue number	11
DOIs	https://doi.org/10.1007/BF01114970
Publication status	Published - Nov 1986
Externally published	Yes

Keywords

Herpes simplex virus
cellular genes
transcriptional induction

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10.1007/BF01114970

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title = "Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus",

abstract = "Herpes simplex virus Type 2 causes a severe repression of host cell biosynthesis at a number of levels. We show that despite this, non-viral cDNA clones derived from cellular RNA species which accumulate to high levels after infection can be isolated using differential screening techniques. By using nuclear run-off assays, we have shown that this RNA accumulation is mediated by transcriptional induction of the corresponding cellular genes.",

keywords = "Herpes simplex virus, cellular genes, transcriptional induction",

author = "Kemp, \{L. M.\} and Brickell, \{P. M.\} and \{La Thangue\}, \{N. B.\} and Latchman, \{D. S.\}",

year = "1986",

month = nov,

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volume = "6",

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journal = "Bioscience Reports",

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T1 - Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus

AU - Kemp, L. M.

AU - Brickell, P. M.

AU - La Thangue, N. B.

AU - Latchman, D. S.

PY - 1986/11

Y1 - 1986/11

N2 - Herpes simplex virus Type 2 causes a severe repression of host cell biosynthesis at a number of levels. We show that despite this, non-viral cDNA clones derived from cellular RNA species which accumulate to high levels after infection can be isolated using differential screening techniques. By using nuclear run-off assays, we have shown that this RNA accumulation is mediated by transcriptional induction of the corresponding cellular genes.

AB - Herpes simplex virus Type 2 causes a severe repression of host cell biosynthesis at a number of levels. We show that despite this, non-viral cDNA clones derived from cellular RNA species which accumulate to high levels after infection can be isolated using differential screening techniques. By using nuclear run-off assays, we have shown that this RNA accumulation is mediated by transcriptional induction of the corresponding cellular genes.

KW - Herpes simplex virus

KW - cellular genes

KW - transcriptional induction

UR - https://www.scopus.com/pages/publications/0022991385

U2 - 10.1007/BF01114970

DO - 10.1007/BF01114970

M3 - Article

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AN - SCOPUS:0022991385

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VL - 6

SP - 945

EP - 951

JO - Bioscience Reports

JF - Bioscience Reports

IS - 11

ER -

Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus

Abstract

Keywords

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