TY - JOUR
T1 - Transition metal based anticancer drugs
AU - Garbutcheon-Singh, K. Benjamin
AU - Grant, Maxine P.
AU - Harper, Benjamin W.
AU - Krause-Heuer, Anwen M.
AU - Manohar, Madhura
AU - Orkey, Nikita
AU - Aldrich-Wright, Janice R.
PY - 2011
Y1 - 2011
N2 - With an ageing baby-boomer population in the Western World, cancer is becoming a significant cause of death. The prevalence of cancer and all associated costs, both in human and financial terms, drives the search for new therapeutic drugs and treatments. Platinum anticancer agents, such as cisplatin have been highly successful but there are several disadvantages associated with their use. What is needed are new compounds with different mechanisms of action and resistance profiles. What needs to be recognised is that there are many other metals in the periodic table with therapeutic potential. Here we have highlighted metal complexes with activity and illustrate the different approaches to the design of anticancer complexes.
AB - With an ageing baby-boomer population in the Western World, cancer is becoming a significant cause of death. The prevalence of cancer and all associated costs, both in human and financial terms, drives the search for new therapeutic drugs and treatments. Platinum anticancer agents, such as cisplatin have been highly successful but there are several disadvantages associated with their use. What is needed are new compounds with different mechanisms of action and resistance profiles. What needs to be recognised is that there are many other metals in the periodic table with therapeutic potential. Here we have highlighted metal complexes with activity and illustrate the different approaches to the design of anticancer complexes.
UR - http://handle.uws.edu.au:8081/1959.7/536604
U2 - 10.2174/156802611794785226
DO - 10.2174/156802611794785226
M3 - Article
SN - 1568-0266
VL - 11
SP - 521
EP - 542
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
IS - 5
ER -
