Tristaenone A : a new anti-inflammatory compound isolated from the Australian Indigenous plant Tristaniopsis laurina

Shintu Mathew; Xian Zhou; Gerald Münch; Francis Bodkin; Matthew Wallis; Feng Li; Ritesh Raju

doi:10.3390/molecules27196592

Tristaenone A : a new anti-inflammatory compound isolated from the Australian Indigenous plant Tristaniopsis laurina

Shintu Mathew, Xian Zhou, Gerald Münch, Francis Bodkin, Matthew Wallis, Feng Li, Ritesh Raju

Western Sydney University

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A (1) suppressed LPS and IFN-γ-induced NO, TNF-α and IL-6 production in RAW 264.7 cells with IC50 values of 37.58 Â± 2.45 μM, 80.6 Â± 5.82 μM and 125.65 Â± 0.34 μM, respectively. It also inhibited NF-κB nuclear translocation by 52.93 Â± 14.14% at a concentration of 31.85 μM.

Original language	English
Article number	6592
Number of pages	8
Journal	Molecules
Volume	27
Issue number	19
DOIs	https://doi.org/10.3390/molecules27196592
Publication status	Published - 2022

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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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abstract = "Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A (1) suppressed LPS and IFN-γ-induced NO, TNF-α and IL-6 production in RAW 264.7 cells with IC50 values of 37.58 {\^A}± 2.45 μM, 80.6 {\^A}± 5.82 μM and 125.65 {\^A}± 0.34 μM, respectively. It also inhibited NF-κB nuclear translocation by 52.93 {\^A}± 14.14% at a concentration of 31.85 μM.",

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AU - Mathew, Shintu

AU - Zhou, Xian

AU - Münch, Gerald

AU - Bodkin, Francis

AU - Wallis, Matthew

AU - Li, Feng

AU - Raju, Ritesh

PY - 2022

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N2 - Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A (1) suppressed LPS and IFN-γ-induced NO, TNF-α and IL-6 production in RAW 264.7 cells with IC50 values of 37.58 Â± 2.45 μM, 80.6 Â± 5.82 μM and 125.65 Â± 0.34 μM, respectively. It also inhibited NF-κB nuclear translocation by 52.93 Â± 14.14% at a concentration of 31.85 μM.

AB - Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A (1) suppressed LPS and IFN-γ-induced NO, TNF-α and IL-6 production in RAW 264.7 cells with IC50 values of 37.58 Â± 2.45 μM, 80.6 Â± 5.82 μM and 125.65 Â± 0.34 μM, respectively. It also inhibited NF-κB nuclear translocation by 52.93 Â± 14.14% at a concentration of 31.85 μM.

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JF - Molecules

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Tristaenone A : a new anti-inflammatory compound isolated from the Australian Indigenous plant Tristaniopsis laurina

Abstract

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