Ultra-high field MRI for evaluation of rectal cancer stroma ex vivo : correlation with histopathology

T. Pham; T. Stait-Gardner; C. S. Lee; M. Barton; G. Liney; K. Wong; W. Price

doi:10.1016/S0167-8140(18)31289-1

Ultra-high field MRI for evaluation of rectal cancer stroma ex vivo : correlation with histopathology

T. Pham, T. Stait-Gardner, C. S. Lee, M. Barton, G. Liney, K. Wong, W. Price

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose or Objective: Current clinical MRI techniques in rectal cancer are unable to differentiate Stage T1 from T2 (invasion of muscularis propria) tumours, and the differentiation of tumour from desmoplastic reaction or fibrous tissue remains a challenge1. Diffusion tensor imaging (DTI) MRI has potential to assess collagen structure and organisation (anisotropy). To our knowledge, there have been no MRI studies assessing DTI MRI for rectal cancer ex vivo. The purpose of this study was to examine DTI MRI derived biomarkers of rectal cancer stromal heterogeneity at high field strength ex vivo.

Original language	English
Pages (from-to)	S541-S542
Number of pages	2
Journal	Radiotherapy and Oncology
Volume	127
Issue number	Suppl. 1
DOIs	https://doi.org/10.1016/S0167-8140(18)31289-1
Publication status	Published - 2018

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Under a Creative Commons license (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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10.1016/S0167-8140(18)31289-1

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title = "Ultra-high field MRI for evaluation of rectal cancer stroma ex vivo : correlation with histopathology",

abstract = "Purpose or Objective: Current clinical MRI techniques in rectal cancer are unable to differentiate Stage T1 from T2 (invasion of muscularis propria) tumours, and the differentiation of tumour from desmoplastic reaction or fibrous tissue remains a challenge1. Diffusion tensor imaging (DTI) MRI has potential to assess collagen structure and organisation (anisotropy). To our knowledge, there have been no MRI studies assessing DTI MRI for rectal cancer ex vivo. The purpose of this study was to examine DTI MRI derived biomarkers of rectal cancer stromal heterogeneity at high field strength ex vivo.",

author = "T. Pham and T. Stait-Gardner and Lee, {C. S.} and M. Barton and G. Liney and K. Wong and W. Price",

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language = "English",

volume = "127",

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TY - JOUR

T1 - Ultra-high field MRI for evaluation of rectal cancer stroma ex vivo : correlation with histopathology

AU - Pham, T.

AU - Stait-Gardner, T.

AU - Lee, C. S.

AU - Barton, M.

AU - Liney, G.

AU - Wong, K.

AU - Price, W.

PY - 2018

Y1 - 2018

N2 - Purpose or Objective: Current clinical MRI techniques in rectal cancer are unable to differentiate Stage T1 from T2 (invasion of muscularis propria) tumours, and the differentiation of tumour from desmoplastic reaction or fibrous tissue remains a challenge1. Diffusion tensor imaging (DTI) MRI has potential to assess collagen structure and organisation (anisotropy). To our knowledge, there have been no MRI studies assessing DTI MRI for rectal cancer ex vivo. The purpose of this study was to examine DTI MRI derived biomarkers of rectal cancer stromal heterogeneity at high field strength ex vivo.

AB - Purpose or Objective: Current clinical MRI techniques in rectal cancer are unable to differentiate Stage T1 from T2 (invasion of muscularis propria) tumours, and the differentiation of tumour from desmoplastic reaction or fibrous tissue remains a challenge1. Diffusion tensor imaging (DTI) MRI has potential to assess collagen structure and organisation (anisotropy). To our knowledge, there have been no MRI studies assessing DTI MRI for rectal cancer ex vivo. The purpose of this study was to examine DTI MRI derived biomarkers of rectal cancer stromal heterogeneity at high field strength ex vivo.

UR - https://hdl.handle.net/1959.7/uws:60215

U2 - 10.1016/S0167-8140(18)31289-1

DO - 10.1016/S0167-8140(18)31289-1

M3 - Article

SN - 0167-8140

VL - 127

SP - S541-S542

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - Suppl. 1

ER -

Ultra-high field MRI for evaluation of rectal cancer stroma ex vivo : correlation with histopathology

Abstract

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