Abstract
Reversed-phase adsorption liquid chromatography was used to successfully resolve diastereomers in a complex mixture of low molecular weight polystyrene oligomers. The separation was achieved by incorporating a two-dimensional liquid chromatography system where the polystyrene oligomers were transported from the first dimensional column, a C18, to an adsorbent phase in the second dimension, a carbon clad zirconia (CCZ) column. Using this system up to 46 diastereomers, each consisting of eight configurational repeat units, were able to be resolved in ultra high separations.
Original language | English |
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Number of pages | 10 |
Journal | Journal of Liquid Chromatography and Related Technologies |
DOIs | |
Publication status | Published - 2007 |
Keywords
- carbon
- diastereoisomers
- liquid chromatography
- oligomers
- polystyrene
- zirconium