Ultra-high resolution separation of diastereomers on carbon adsorption stationary phases

Coleen S. Milroy, Gary R. Dennis, Ross A. Shalliker

    Research output: Contribution to journalArticle

    Abstract

    Reversed-phase adsorption liquid chromatography was used to successfully resolve diastereomers in a complex mixture of low molecular weight polystyrene oligomers. The separation was achieved by incorporating a two-dimensional liquid chromatography system where the polystyrene oligomers were transported from the first dimensional column, a C18, to an adsorbent phase in the second dimension, a carbon clad zirconia (CCZ) column. Using this system up to 46 diastereomers, each consisting of eight configurational repeat units, were able to be resolved in ultra high separations.
    Original languageEnglish
    Number of pages10
    JournalJournal of Liquid Chromatography and Related Technologies
    DOIs
    Publication statusPublished - 2007

    Keywords

    • carbon
    • diastereoisomers
    • liquid chromatography
    • oligomers
    • polystyrene
    • zirconium

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