Unravelling the role of solid lipid nanoparticles in drug delivery: Journey from laboratory to clinical trial

Vancha Harish; Sharfuddin Mohd; Devesh Tewari; Narendra Kumar Pandey; Sukriti Vishwas; Malakapogu Ravindra Babu; Mohamad Ayman Salkini; Zia ur Rehman; Jehan Talaq Alotaibi; Renad Fahad Alotaibi; Fahad Abdulaziz Alrashed; Parteek Prasher; Nitin Sharma; Gaurav Gupta; Vikash Jakhmola; Yogendra Singh; Terezinha de Jesus Andreoli Pinto; Keshav Raj Paudel; Neeraj Mittal; Thakur Gurjeet Singh; Poonam Arora; Kamal Dua; Sachin Kumar Singh

doi:10.1016/j.jddst.2023.104616

Unravelling the role of solid lipid nanoparticles in drug delivery: Journey from laboratory to clinical trial

Vancha Harish
, Sharfuddin Mohd
, Devesh Tewari
, Narendra Kumar Pandey
, Sukriti Vishwas
, Malakapogu Ravindra Babu
, Mohamad Ayman Salkini
, Zia ur Rehman
, Jehan Talaq Alotaibi
, Renad Fahad Alotaibi
, Fahad Abdulaziz Alrashed
, Parteek Prasher
, Nitin Sharma
, Gaurav Gupta
, Vikash Jakhmola
, Yogendra Singh
, Terezinha de Jesus Andreoli Pinto
, Keshav Raj Paudel
, Neeraj Mittal
, Thakur Gurjeet Singh

Poonam Arora, Kamal Dua, Sachin Kumar Singh

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

In current years, solid lipid nanoparticles (SLNs) have gained tremendous interest in research because of their unique characteristics such as encapsulation of drug in their core, targeted drug delivery and their protection from gastrointestinal environment and first pass metabolism of various potential bioactive drugs including proteins, peptides and phytochemicals. The present review discusses the historical background and transformation taken place in the nanotechnology that led to the development of SLNs. Further, the study entailed about the composition, various ingredients and techniques that are used to fabricate SLNs along with their mechanism and advantages. Highlighted are the biopharmaceutical aspects and bottle necks associated to clinical translation of SLNs for improving the bioavailability, stability, and solubility of various lipophilic and gastrointestinal labile drugs that are used for treating many chronic diseases.

Original language	English
Article number	104616
Journal	Journal of Drug Delivery Science and Technology
Volume	85
DOIs	https://doi.org/10.1016/j.jddst.2023.104616
Publication status	Published - Aug 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 Elsevier B.V.

Keywords

Biopharmaceutical aspects
Oral bioavailability
Solid lipid nanoparticles
Solubility

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10.1016/j.jddst.2023.104616

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Harish, V., Mohd, S., Tewari, D., Pandey, N. K., Vishwas, S., Babu, M. R., Salkini, M. A., Rehman, Z. U., Alotaibi, J. T., Alotaibi, R. F., Alrashed, F. A., Prasher, P., Sharma, N., Gupta, G., Jakhmola, V., Singh, Y., Pinto, T. D. J. A., Paudel, K. R., Mittal, N., ... Singh, S. K. (2023). Unravelling the role of solid lipid nanoparticles in drug delivery: Journey from laboratory to clinical trial. Journal of Drug Delivery Science and Technology, 85, Article 104616. https://doi.org/10.1016/j.jddst.2023.104616

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title = "Unravelling the role of solid lipid nanoparticles in drug delivery: Journey from laboratory to clinical trial",

abstract = "In current years, solid lipid nanoparticles (SLNs) have gained tremendous interest in research because of their unique characteristics such as encapsulation of drug in their core, targeted drug delivery and their protection from gastrointestinal environment and first pass metabolism of various potential bioactive drugs including proteins, peptides and phytochemicals. The present review discusses the historical background and transformation taken place in the nanotechnology that led to the development of SLNs. Further, the study entailed about the composition, various ingredients and techniques that are used to fabricate SLNs along with their mechanism and advantages. Highlighted are the biopharmaceutical aspects and bottle necks associated to clinical translation of SLNs for improving the bioavailability, stability, and solubility of various lipophilic and gastrointestinal labile drugs that are used for treating many chronic diseases.",

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author = "Vancha Harish and Sharfuddin Mohd and Devesh Tewari and Pandey, \{Narendra Kumar\} and Sukriti Vishwas and Babu, \{Malakapogu Ravindra\} and Salkini, \{Mohamad Ayman\} and Rehman, \{Zia ur\} and Alotaibi, \{Jehan Talaq\} and Alotaibi, \{Renad Fahad\} and Alrashed, \{Fahad Abdulaziz\} and Parteek Prasher and Nitin Sharma and Gaurav Gupta and Vikash Jakhmola and Yogendra Singh and Pinto, \{Terezinha de Jesus Andreoli\} and Paudel, \{Keshav Raj\} and Neeraj Mittal and Singh, \{Thakur Gurjeet\} and Poonam Arora and Kamal Dua and Singh, \{Sachin Kumar\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = aug,

doi = "10.1016/j.jddst.2023.104616",

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volume = "85",

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Harish, V, Mohd, S, Tewari, D, Pandey, NK, Vishwas, S, Babu, MR, Salkini, MA, Rehman, ZU, Alotaibi, JT, Alotaibi, RF, Alrashed, FA, Prasher, P, Sharma, N, Gupta, G, Jakhmola, V, Singh, Y, Pinto, TDJA, Paudel, KR, Mittal, N, Singh, TG, Arora, P, Dua, K & Singh, SK 2023, 'Unravelling the role of solid lipid nanoparticles in drug delivery: Journey from laboratory to clinical trial', Journal of Drug Delivery Science and Technology, vol. 85, 104616. https://doi.org/10.1016/j.jddst.2023.104616

TY - JOUR

T1 - Unravelling the role of solid lipid nanoparticles in drug delivery

T2 - Journey from laboratory to clinical trial

AU - Harish, Vancha

AU - Mohd, Sharfuddin

AU - Tewari, Devesh

AU - Pandey, Narendra Kumar

AU - Vishwas, Sukriti

AU - Babu, Malakapogu Ravindra

AU - Salkini, Mohamad Ayman

AU - Rehman, Zia ur

AU - Alotaibi, Jehan Talaq

AU - Alotaibi, Renad Fahad

AU - Alrashed, Fahad Abdulaziz

AU - Prasher, Parteek

AU - Sharma, Nitin

AU - Gupta, Gaurav

AU - Jakhmola, Vikash

AU - Singh, Yogendra

AU - Pinto, Terezinha de Jesus Andreoli

AU - Paudel, Keshav Raj

AU - Mittal, Neeraj

AU - Singh, Thakur Gurjeet

AU - Arora, Poonam

AU - Dua, Kamal

AU - Singh, Sachin Kumar

PY - 2023/8

Y1 - 2023/8

N2 - In current years, solid lipid nanoparticles (SLNs) have gained tremendous interest in research because of their unique characteristics such as encapsulation of drug in their core, targeted drug delivery and their protection from gastrointestinal environment and first pass metabolism of various potential bioactive drugs including proteins, peptides and phytochemicals. The present review discusses the historical background and transformation taken place in the nanotechnology that led to the development of SLNs. Further, the study entailed about the composition, various ingredients and techniques that are used to fabricate SLNs along with their mechanism and advantages. Highlighted are the biopharmaceutical aspects and bottle necks associated to clinical translation of SLNs for improving the bioavailability, stability, and solubility of various lipophilic and gastrointestinal labile drugs that are used for treating many chronic diseases.

AB - In current years, solid lipid nanoparticles (SLNs) have gained tremendous interest in research because of their unique characteristics such as encapsulation of drug in their core, targeted drug delivery and their protection from gastrointestinal environment and first pass metabolism of various potential bioactive drugs including proteins, peptides and phytochemicals. The present review discusses the historical background and transformation taken place in the nanotechnology that led to the development of SLNs. Further, the study entailed about the composition, various ingredients and techniques that are used to fabricate SLNs along with their mechanism and advantages. Highlighted are the biopharmaceutical aspects and bottle necks associated to clinical translation of SLNs for improving the bioavailability, stability, and solubility of various lipophilic and gastrointestinal labile drugs that are used for treating many chronic diseases.

KW - Biopharmaceutical aspects

KW - Oral bioavailability

KW - Solid lipid nanoparticles

KW - Solubility

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U2 - 10.1016/j.jddst.2023.104616

DO - 10.1016/j.jddst.2023.104616

M3 - Article

AN - SCOPUS:85160856743

SN - 1773-2247

VL - 85

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

M1 - 104616

ER -

Unravelling the role of solid lipid nanoparticles in drug delivery: Journey from laboratory to clinical trial

Abstract

Bibliographical note

Keywords

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