UPBEAT, RADIEL, and DALI : what's the difference?

David Simmons, Mireille N. M. van Poppel

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    12 Citations (Scopus)

    Abstract

    We congratulate Poston and colleagues1 on completion of UPBEAT, a meticulous randomised controlled trial. Unfortunately, their combined healthy eating and physical activity intervention, as with the older LIMIT trial, 2 did not prevent gestational diabetes compared with standard antenatal care. We subsequently published the DALI Lifestyle Pilot3 showing that women in our healthy eating intervention gained less weight (–2•6 kg [95% CI –4•9 to –0•2]), with a greater decrease in fasting glucose (–0•3 mmol/L [–0•4 to –0•1]) and a non-significant 33% reduction in gestational diabetes, compared with the physical activity intervention (odds ratio 0•67 [95% CI 0•25; 1•75; p=0•41]). On July 29, another randomised controlled trial4 of a healthy eating and physical activity intervention (RADIEL) reported a 39% (2–60) reduction in gestational diabetes, although this result was only significant after adjustment for baseline data (which were similar between groups).
    Original languageEnglish
    Pages (from-to)761-761
    Number of pages1
    JournalLancet Diabetes and Endocrinology
    Volume3
    Issue number10
    DOIs
    Publication statusPublished - 2015

    Keywords

    • diabetes in pregnancy
    • insulin
    • prenatal care

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