Uterine Artery Pulsatility Index Assessment at <11 Weeks' Gestation : A Prospective Study

T.J. Taylor, A.E. Quinton, Vries De, J.A. Hyett

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Objective: Mean uterine artery pulsatility index (meanUAPI) is commonly measured at 11-13+6 weeks to predict adverse pregnancy outcomes including hypertensive disorders and small-for-gestational age. The aims of this study were to establish a population-specific reference range for meanUAPI at &lt;11 weeks, to determine if an abnormal meanUAPI at &lt;11 weeks was associated with adverse pregnancy outcome, and to assess changes in meanUAPI between &lt;11 weeks and 11-13+6 weeks. Methods: A prospective cohort was examined at &lt;11 weeks and at 11-13+6 weeks to develop reference ranges for meanUAPI. Based on these regression models, meanUAPI Z-scores were compared between outcome groups using a two-sample t test. Longitudinal changes in the meanUAPI between &lt;11 and 11-13+6 weeks were assessed by two-way mixed ANOVA. Results: Prior to 11 weeks, there was no significant difference in meanUAPI between normal (n = 622) and adverse (n = 80) outcomes (mean [95% CI]: 2.62 [2.57-2.67] and 2.67 [2.50-2.84], respectively; p = 0.807). At 11-13+6 weeks, meanUAPI was significantly higher in the adverse (n = 66) compared with the normal (n = 535) outcome group (mean [95% CI]: 1.87 [1.70-2.03] and 1.67 [1.63-1.72], respectively; p = 0.040). There was a statistically significant decrease (p &lt; 0.0001) in meanUAPI between the two time points. Conclusion: MeanUAPI measured at &lt;11 weeks' gestation does not appear to be a useful marker for the prediction of placental-related adverse pregnancy outcomes, supporting an argument for the prediction of risk at 11-13+6 weeks' gestation.
Original languageEnglish
Pages (from-to)129-137
Number of pages9
JournalFetal Diagnosis and Therapy
Volume47
Issue number2
DOIs
Publication statusPublished - 2020

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