Utilizing the enhanced permeability and retention (EPR) effect : theranostic star polymers

Jeroen Goos; Thomas Dilling; Maria Davydova; Andrew Cho; Simon Puttick; Abhishek Gupta; William Price; John Quinn; Michael Whittaker; Jason Lewis; Thomas Davis

Utilizing the enhanced permeability and retention (EPR) effect : theranostic star polymers

Jeroen Goos, Thomas Dilling, Maria Davydova, Andrew Cho, Simon Puttick, Abhishek Gupta, William Price, John Quinn, Michael Whittaker, Jason Lewis, Thomas Davis

Western Sydney University

Research output: Chapter in Book / Conference Paper › Conference Paper

Abstract

![CDATA[Introduction: The targeting of tumor cells often relies on the availability of cancer-associated biomarkers at the tumor site. In general, however, expression levels of such biomarkers are unknown at initial diagnosis. To enable accumulation of theranostic agents independent of biomarker availability, star nanoparticles were developed, consisting of center-crosslinked arms functionalized with imaging components (Gd for MRI) and therapeutic components ( Lu for endoradiotherapy), that may utilize the enhanced permeability and retention (EPR) effect for passive tumor targeting.]]

Original language	English
Title of host publication	14th European Molecular Imaging Meeting (EMIM 2019), March 19 - 22, 2019, Scottish Event Campus Centre, Glasgow, U.K.
Publisher	European Society for Molecular Imaging
Number of pages	1
Publication status	Published - 2019
Event	European Molecular Imaging Meeting - Duration: 1 Jan 2019 → …

Conference

Conference	European Molecular Imaging Meeting
Period	1/01/19 → …

Cite this

Goos, J., Dilling, T., Davydova, M., Cho, A., Puttick, S., Gupta, A., Price, W., Quinn, J., Whittaker, M., Lewis, J., & Davis, T. (2019). Utilizing the enhanced permeability and retention (EPR) effect : theranostic star polymers. In 14th European Molecular Imaging Meeting (EMIM 2019), March 19 - 22, 2019, Scottish Event Campus Centre, Glasgow, U.K. European Society for Molecular Imaging.

@inproceedings{077dd56da5e2475baba2da3a9157e320,

title = "Utilizing the enhanced permeability and retention (EPR) effect : theranostic star polymers",

abstract = "![CDATA[Introduction: The targeting of tumor cells often relies on the availability of cancer-associated biomarkers at the tumor site. In general, however, expression levels of such biomarkers are unknown at initial diagnosis. To enable accumulation of theranostic agents independent of biomarker availability, star nanoparticles were developed, consisting of center-crosslinked arms functionalized with imaging components (Gd for MRI) and therapeutic components ( Lu for endoradiotherapy), that may utilize the enhanced permeability and retention (EPR) effect for passive tumor targeting.]]",

author = "Jeroen Goos and Thomas Dilling and Maria Davydova and Andrew Cho and Simon Puttick and Abhishek Gupta and William Price and John Quinn and Michael Whittaker and Jason Lewis and Thomas Davis",

year = "2019",

language = "English",

booktitle = "14th European Molecular Imaging Meeting (EMIM 2019), March 19 - 22, 2019, Scottish Event Campus Centre, Glasgow, U.K.",

publisher = "European Society for Molecular Imaging",

note = "European Molecular Imaging Meeting ; Conference date: 01-01-2019",

}

Goos, J, Dilling, T, Davydova, M, Cho, A, Puttick, S, Gupta, A, Price, W, Quinn, J, Whittaker, M, Lewis, J & Davis, T 2019, Utilizing the enhanced permeability and retention (EPR) effect : theranostic star polymers. in 14th European Molecular Imaging Meeting (EMIM 2019), March 19 - 22, 2019, Scottish Event Campus Centre, Glasgow, U.K.. European Society for Molecular Imaging, European Molecular Imaging Meeting, 1/01/19.

Utilizing the enhanced permeability and retention (EPR) effect : theranostic star polymers. / Goos, Jeroen; Dilling, Thomas; Davydova, Maria et al.
14th European Molecular Imaging Meeting (EMIM 2019), March 19 - 22, 2019, Scottish Event Campus Centre, Glasgow, U.K.. European Society for Molecular Imaging, 2019.

Research output: Chapter in Book / Conference Paper › Conference Paper

TY - GEN

T1 - Utilizing the enhanced permeability and retention (EPR) effect : theranostic star polymers

AU - Goos, Jeroen

AU - Dilling, Thomas

AU - Davydova, Maria

AU - Cho, Andrew

AU - Puttick, Simon

AU - Gupta, Abhishek

AU - Price, William

AU - Quinn, John

AU - Whittaker, Michael

AU - Lewis, Jason

AU - Davis, Thomas

PY - 2019

Y1 - 2019

N2 - ![CDATA[Introduction: The targeting of tumor cells often relies on the availability of cancer-associated biomarkers at the tumor site. In general, however, expression levels of such biomarkers are unknown at initial diagnosis. To enable accumulation of theranostic agents independent of biomarker availability, star nanoparticles were developed, consisting of center-crosslinked arms functionalized with imaging components (Gd for MRI) and therapeutic components ( Lu for endoradiotherapy), that may utilize the enhanced permeability and retention (EPR) effect for passive tumor targeting.]]

AB - ![CDATA[Introduction: The targeting of tumor cells often relies on the availability of cancer-associated biomarkers at the tumor site. In general, however, expression levels of such biomarkers are unknown at initial diagnosis. To enable accumulation of theranostic agents independent of biomarker availability, star nanoparticles were developed, consisting of center-crosslinked arms functionalized with imaging components (Gd for MRI) and therapeutic components ( Lu for endoradiotherapy), that may utilize the enhanced permeability and retention (EPR) effect for passive tumor targeting.]]

UR - https://hdl.handle.net/1959.7/uws:61175

M3 - Conference Paper

BT - 14th European Molecular Imaging Meeting (EMIM 2019), March 19 - 22, 2019, Scottish Event Campus Centre, Glasgow, U.K.

PB - European Society for Molecular Imaging

T2 - European Molecular Imaging Meeting

Y2 - 1 January 2019

ER -

Utilizing the enhanced permeability and retention (EPR) effect : theranostic star polymers

Abstract

Conference

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