Xanthine oxidase inhibitory activity of selected Australian native plants

Alan P. Sweeney; S. Grant Wyllie; Ross A. Shalliker; Julie Markham

doi:10.1016/S0378-8741(01)00176-3

Xanthine oxidase inhibitory activity of selected Australian native plants

Alan P. Sweeney, S. Grant Wyllie, Ross A. Shalliker, Julie Markham

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130 Citations (Scopus)

Abstract

Twenty-eight extracts from 17 species of Australian native plants traditionally used as general anti-inflammatory medicines by Australian Aboriginal people were examined for inhibition of the enzyme xanthine oxidase (XO). The extracts from nine species were found to have more than 25% inhibition at a concentration of 100 μg/ml in the assay mixture. Extracts from three species Clerodendrum floribundum R. Br. (Verbenaceae), Eremophila maculata (Ker Gawler) (Myoporaceae) and Stemodia grossa Benth. (Scrophulariaceae) showed the greatest activity with inhibitions of 84, 61 and 57%, respectively, at 50 μg/ml, with four other species having more than 40% inhibitory activity at this concentration.

Original language	English
Pages (from-to)	273-277
Number of pages	5
Journal	Journal of Ethnopharmacology
Volume	75
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-8741(01)00176-3
Publication status	Published - 2001

Keywords

Aboriginal Australians
Analysis
Anti-inflammatory agents
Australia
Medicinal plants
Medicine
Bioassay
Australian native plants
Eremophila
Clerodendrum
Stemodia
Xanthine oxidase
Anti-inflammatory

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10.1016/S0378-8741(01)00176-3

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title = "Xanthine oxidase inhibitory activity of selected Australian native plants",

abstract = "Twenty-eight extracts from 17 species of Australian native plants traditionally used as general anti-inflammatory medicines by Australian Aboriginal people were examined for inhibition of the enzyme xanthine oxidase (XO). The extracts from nine species were found to have more than 25% inhibition at a concentration of 100 μg/ml in the assay mixture. Extracts from three species Clerodendrum floribundum R. Br. (Verbenaceae), Eremophila maculata (Ker Gawler) (Myoporaceae) and Stemodia grossa Benth. (Scrophulariaceae) showed the greatest activity with inhibitions of 84, 61 and 57%, respectively, at 50 μg/ml, with four other species having more than 40% inhibitory activity at this concentration.",

keywords = "Aboriginal Australians, Analysis, Anti-inflammatory agents, Australia, Medicinal plants, Medicine, Bioassay, Australian native plants, Eremophila, Clerodendrum, Stemodia, Xanthine oxidase, Anti-inflammatory",

author = "Sweeney, {Alan P.} and Wyllie, {S. Grant} and Shalliker, {Ross A.} and Julie Markham",

year = "2001",

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T1 - Xanthine oxidase inhibitory activity of selected Australian native plants

AU - Sweeney, Alan P.

AU - Wyllie, S. Grant

AU - Shalliker, Ross A.

AU - Markham, Julie

PY - 2001

Y1 - 2001

N2 - Twenty-eight extracts from 17 species of Australian native plants traditionally used as general anti-inflammatory medicines by Australian Aboriginal people were examined for inhibition of the enzyme xanthine oxidase (XO). The extracts from nine species were found to have more than 25% inhibition at a concentration of 100 μg/ml in the assay mixture. Extracts from three species Clerodendrum floribundum R. Br. (Verbenaceae), Eremophila maculata (Ker Gawler) (Myoporaceae) and Stemodia grossa Benth. (Scrophulariaceae) showed the greatest activity with inhibitions of 84, 61 and 57%, respectively, at 50 μg/ml, with four other species having more than 40% inhibitory activity at this concentration.

AB - Twenty-eight extracts from 17 species of Australian native plants traditionally used as general anti-inflammatory medicines by Australian Aboriginal people were examined for inhibition of the enzyme xanthine oxidase (XO). The extracts from nine species were found to have more than 25% inhibition at a concentration of 100 μg/ml in the assay mixture. Extracts from three species Clerodendrum floribundum R. Br. (Verbenaceae), Eremophila maculata (Ker Gawler) (Myoporaceae) and Stemodia grossa Benth. (Scrophulariaceae) showed the greatest activity with inhibitions of 84, 61 and 57%, respectively, at 50 μg/ml, with four other species having more than 40% inhibitory activity at this concentration.

KW - Aboriginal Australians

KW - Analysis

KW - Anti-inflammatory agents

KW - Australia

KW - Medicinal plants

KW - Medicine

KW - Bioassay

KW - Australian native plants

KW - Eremophila

KW - Clerodendrum

KW - Stemodia

KW - Xanthine oxidase

KW - Anti-inflammatory

UR - http://handle.uws.edu.au:8081/1959.7/10649

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DO - 10.1016/S0378-8741(01)00176-3

M3 - Article

SN - 0378-8741

VL - 75

SP - 273

EP - 277

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 2-3

ER -

Xanthine oxidase inhibitory activity of selected Australian native plants

Abstract

Keywords

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