Ziziphus spinosa seeds for insomnia : a review of chemistry and psychopharmacology

Johannah Linda Shergis; Xiaojia Ni; Jerome Sarris; Anthony Lin Zhang; Xinfeng Guo; Charlie C. Xue; Chuanjian Lu; Helmut Hugel

doi:10.1016/j.phymed.2017.07.004

Ziziphus spinosa seeds for insomnia : a review of chemistry and psychopharmacology

Johannah Linda Shergis, Xiaojia Ni, Jerome Sarris, Anthony Lin Zhang, Xinfeng Guo, Charlie C. Xue, Chuanjian Lu, Helmut Hugel

Western Sydney University

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Background In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia. Purpose/Sections This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies. Conclusions ZS secondary metabolites modulate GABAergic activity and the serotonergic system. The actual therapeutic agents require further confirmation/identification so that new insomnia phytomedicines can be discovered.

Original language	English
Pages (from-to)	38-43
Number of pages	6
Journal	Phytomedicine
Volume	34
DOIs	https://doi.org/10.1016/j.phymed.2017.07.004
Publication status	Published - 2017

Keywords

herbs
insomnia
medicine_Chinese
psychopharmacology

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10.1016/j.phymed.2017.07.004

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abstract = "Background In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia. Purpose/Sections This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies. Conclusions ZS secondary metabolites modulate GABAergic activity and the serotonergic system. The actual therapeutic agents require further confirmation/identification so that new insomnia phytomedicines can be discovered.",

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author = "Shergis, {Johannah Linda} and Xiaojia Ni and Jerome Sarris and Zhang, {Anthony Lin} and Xinfeng Guo and Xue, {Charlie C.} and Chuanjian Lu and Helmut Hugel",

year = "2017",

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T1 - Ziziphus spinosa seeds for insomnia : a review of chemistry and psychopharmacology

AU - Shergis, Johannah Linda

AU - Ni, Xiaojia

AU - Sarris, Jerome

AU - Zhang, Anthony Lin

AU - Guo, Xinfeng

AU - Xue, Charlie C.

AU - Lu, Chuanjian

AU - Hugel, Helmut

PY - 2017

Y1 - 2017

N2 - Background In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia. Purpose/Sections This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies. Conclusions ZS secondary metabolites modulate GABAergic activity and the serotonergic system. The actual therapeutic agents require further confirmation/identification so that new insomnia phytomedicines can be discovered.

AB - Background In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia. Purpose/Sections This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies. Conclusions ZS secondary metabolites modulate GABAergic activity and the serotonergic system. The actual therapeutic agents require further confirmation/identification so that new insomnia phytomedicines can be discovered.

KW - herbs

KW - insomnia

KW - medicine_Chinese

KW - psychopharmacology

UR - https://hdl.handle.net/1959.7/uws:62538

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DO - 10.1016/j.phymed.2017.07.004

M3 - Article

SN - 0944-7113

VL - 34

SP - 38

EP - 43

JO - Phytomedicine

JF - Phytomedicine

ER -

Ziziphus spinosa seeds for insomnia : a review of chemistry and psychopharmacology

Abstract

Keywords

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