The binding of mono- and dinuclear platinum(II) complexes with both double-stranded and G-quadruplex DNA (QDNA) was explored using a combination of spectroscopic and computational techniques. The stabilising effects on G-quadruplex DNA were assessed and structure-activity relationships developed to guide the future development of QDNA selective complexes. Additionally, two pieces of software were developed, each able to process spectroscopic information. The first application calculates binding constants from various spectroscopic data including circular dichroism and fluorescence. The second program, SOMSpec, uses a machine learning approach to elucidate biomacromolecular structure from circular dichroism and infrared spectra.
| Date of Award | 2019 |
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| Original language | English |
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- quadruplex nucleic acids
- platinum compounds
- structure-activity relationships (biochemistry)
- physical biochemistry
- data processing
- computer simulation
Biophysical and computational studies of biomacromolecular systems
Ang, D. (Author). 2019
Western Sydney University thesis: Doctoral thesis