In vivo evaluation of "Meriva" curcumin, and apigenin as anti-inflammatory drugs in a mouse model of chronic neuroinflammation

Abstract

Purpose: The current project was divided into two separate, but related studies: the curcumin project and the apigenin project. In these projects, we aimed to assess the potential of two polyphenolic compounds in treating neuroinflammation and neurodegenerative disease: curcumin and apigenin. Curcumin project purpose (pilot study): To develop a valid UPLC-MS/MS method to quantify the plasma concentration of a phosphatidylcholine curcumin formulation (Meriva® curcumin), administered orally (via chow) to GFAP-IL6 mice for 30 days. We also endeavoured to determine if this formulation is able to increase bioavailability of Meriva® curcumin, in comparison to unformulated curcumin (nai¨ve curcumin). We also aimed to confirm, using spectrophotometry, the curcumin concentration within the chow, in order to validate our experiment. Apigenin project purpose: To assess the viability of apigenin in rescuing motor, learning and memory deficits in a GFAP-IL6 mouse model of chronic neuroinflammation.

Date of Award	2018
Original language	English