Studies on the aetiopathogenesis of type I autoimmune diabetes

Abstract

It is well recognised that every disease has both genetic and environmental causes. There are indications that environmental factors may play a crucial role over a limited period of time in genetically susceptible individuals to initiate the pancreatic insulin producing beta-cells autoimmune process. No causal links between environmental triggering factors and the pancreatic autoimmune process have yet been identified unequivocally. Although the occurrence of autoimmune diabetes in Jordan is increasing by approximately one percent annually, studies on diabetes in young Jordanian children remain limited. Therefore, the rationale of this study hinges upon establishing a base-line dietary profile, and determining possible humoral and secretory immune response to native and heat processed bovine serum albumin modified with bovine insulin in young Jordanian children with diabetes. To minimise the increasing occurrence of the disease through proposing safe and inexpensive preventative interventions of the disease, this study is directed at improving the understanding of the aetiopathogenesis of the disease by participating in identifying potential primary environmental triggering factors. Obviously, the health care system is a vital element in every society to maintain people's health of the highest standard.

Date of Award	2006
Original language	English